SPATIAL DOWNREGULATION OF CD74 SIGNATURES MAY DRIVE INVASIVE COMPONENT DEVELOPMENT IN PART-SOLID LUNG ADENOCARCINOMA

Spatial downregulation of CD74 signatures may drive invasive component development in part-solid lung adenocarcinoma

House Summary: Pulmonary nodules with part-solid imaging features manifest during the progression from preinvasive to invasive lung adenocarcinoma.To define the spatial composition and evolutionary trajectories of early-stage lung adenocarcinoma, we combined spatial transcriptomics (ST) and pathological annotations from 20 part-solid nodules (PSNs)

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Adsorption and desorption of Hg(II) by four aged microplastics and its effects on gaseous elemental mercury production in seawater

Microplastics (MPs) weather after entering the environment gradually, and the interaction with metal ions in the aqueous environment has received extensive attention.However, there are few studies on Hg(Ⅱ), especially the effect of MPs on the release of Hg0(DEM) in water after entering the aqueous environment.In this study, four types of MPs (PP,

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An extensible mathematical model of glucose metabolism. Part I: the basic glucose-insulin-glucagon model, basal conditions and basic dynamics

Gastrointestinal - Probiotics A basic model highlighting the counter-regulatory roles of insulin and glucagon is proposed to start a series of models designed to explore continuous rein control and major aspects of glucose metabolism.The three-by-three dynamical system uses black boxes to model unit processes such as the dependencies of insulin sec

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